📊 VC Pulse

Venture Capital Intelligence Report

February 25, 2026 • Synthesizing insights from top-tier VCs

🌍 Macro Outlook

Overall Sentiment

CAUTIOUS

Key Themes

AI Infrastructure MaturationPost-ZIRP DisciplineEnterprise AI Consolidation

Market View

VCs see selective strength in tech markets, with AI infrastructure spending driving valuations while traditional SaaS multiples compress. Focus shifting from growth-at-all-costs to sustainable unit economics.

Funding Environment

Series A crunch continues as VCs demand clearer path to profitability. Seed funding remains active for AI/climate tech. Growth rounds reserved for proven business models with strong fundamentals.

Valuation Trends

AI infrastructure companies trading at 15-25x revenue, enterprise SaaS at 6-10x (down from 2021 peaks). Early-stage valuations stabilizing after 2023-2024 reset.

🔥 Hot Sectors

AI Infrastructure & Tooling 🔥🔥🔥 HOT

The picks-and-shovels play for the AI gold rush. Every enterprise needs AI infrastructure, creating massive TAM with sticky revenue models.

📈 Stage: Series A 🏢 Examples: Weights & Biases, Modal, Pinecone
Key Opportunities:
  • Model deployment platforms
  • GPU orchestration
  • AI observability
Risks:
  • Hyperscaler competition
  • Open source alternatives
a16zIndexLightspeedGeneral Catalyst
Vertical AI Agents 🔥🔥🔥 HOT

AI agents that automate specific workflows in industries like legal, healthcare, finance are showing clear ROI and customer willingness to pay premium prices.

📈 Stage: Seed 🏢 Examples: Harvey, Glean, Perplexity for Enterprise
Key Opportunities:
  • Legal research automation
  • Medical coding
  • Financial analysis
Risks:
  • Accuracy liability
  • Regulatory hurdles
SequoiaGreylockAccel
Climate Infrastructure 🔥🔥 WARM

Policy tailwinds + corporate ESG commitments creating predictable demand. Focus on profitable climate solutions with clear unit economics.

📈 Stage: Growth 🏢 Examples: Form Energy, Sila Nanotechnologies, Commonwealth Fusion
Key Opportunities:
  • Grid modernization
  • Industrial decarbonization
  • Carbon management
Risks:
  • Policy reversal risk
  • Long development cycles
KleinerBreakthrough EnergyBessemer
Defense Tech 🔥🔥 WARM

Geopolitical tensions driving defense modernization. Government willing to pay premium for advanced capabilities, creating venture-scalable opportunities.

📈 Stage: Series A 🏢 Examples: Anduril, Shield AI, Relativity Space
Key Opportunities:
  • Autonomous systems
  • Cybersecurity
  • Space technology
Risks:
  • Export restrictions
  • Government customer risk
Andreessen HorowitzGeneral CatalystAccel
Fintech Infrastructure 🔥🔥 WARM

B2B fintech infrastructure proving more durable than consumer fintech. Banks need modern infrastructure, creating long-term partnership opportunities.

📈 Stage: Series A 🏢 Examples: Unit, Modern Treasury, Alloy
Key Opportunities:
  • Banking-as-a-Service
  • Compliance automation
  • Real-time payments
Risks:
  • Regulatory complexity
  • Bank partnership risk
IndexLightspeedSequoia

🔦 VC Spotlight

Andreessen Horowitz
Katherine Boyle
2026-02-20
American Dynamism - investing in companies that support national interests

Technology companies serving government and critical infrastructure represent massive underinvested opportunity with predictable revenue streams

"The next generation of great companies will be built in partnership with, not in opposition to, government institutions"
Defense TechGov TechInfrastructure
Contrarian View: Government as customer is feature, not bug - provides stability and scale
Sequoia Capital
Pat Grady
2026-02-18
The Arc of AI Adoption in Enterprise

Enterprise AI adoption following predictable pattern: infrastructure first, then horizontal tools, finally vertical applications

"We're still in the infrastructure phase. The real value creation happens when AI gets embedded in specific workflows"
AI InfrastructureVertical SaaSDeveloper Tools
Contrarian View: Horizontal AI tools will be commoditized; vertical AI applications will capture most value
Kleiner Perkins
Mamoon Hamid
2026-02-15
Climate Tech 2.0 - Moving Beyond Clean Energy

Climate tech opportunity extends far beyond renewable energy into industrial processes, materials, and agriculture

"Climate tech is becoming just tech. Every industrial process will be reimagined through a climate lens"
Industrial TechMaterials ScienceAgTech
Contrarian View: Software-driven climate solutions will scale faster than hardware-heavy approaches
Index Ventures
Sarah Cannon
2026-02-12
European AI Advantage in Vertical Applications

European startups have structural advantages in regulated verticals like healthcare and finance due to GDPR expertise

"Privacy-first AI development isn't a constraint - it's a competitive moat"
Healthcare AIRegTechPrivacy-preserving ML
Contrarian View: European regulatory experience will become global competitive advantage as AI regulation spreads
Greylock Partners
Reid Hoffman
2026-02-10
The Consumerization of Enterprise AI

Best enterprise AI tools will have consumer-grade UX, driving bottom-up adoption within organizations

"The next Slack for AI is being built right now. It won't feel like enterprise software"
AI Productivity ToolsCollaboration SoftwareDeveloper Experience
Contrarian View: Top-down AI sales will lose to bottom-up viral adoption

🌱 Emerging Themes

🌱 AI Regulation as Moat Mainstream adoption by 2027 as regulations enforce

Companies building AI compliance and governance tools as regulatory frameworks emerge globally

Why Now:

EU AI Act implementation, US executive orders creating compliance requirements for AI deployment

Market Potential:

$50B+ market as every AI deployment needs governance layer

Early signals from: Index, Accel, General Catalyst

Companies to watch: Fiddler AI, Arthur AI, Credo AI

🌱 Spatial Computing Infrastructure Enterprise adoption accelerates 2026-2027

Backend infrastructure for AR/VR applications as Apple Vision Pro catalyzes market

Why Now:

Vision Pro proving enterprise use cases, need for spatial computing cloud infrastructure

Market Potential:

$30B+ market as spatial computing goes mainstream

Early signals from: Benchmark, Lightspeed, Greylock

Companies to watch: 8th Wall, Niantic, Looking Glass Factory

🌱 Bio-Manufacturing Automation Commercial deployments scaling through 2026-2028

AI and robotics applied to bioprocessing and pharmaceutical manufacturing

Why Now:

Pandemic highlighted supply chain vulnerabilities, AI enabling personalized medicine scale

Market Potential:

$100B+ opportunity in pharmaceutical manufacturing efficiency

Early signals from: Kleiner, Bessemer, General Catalyst

Companies to watch: Ginkgo Bioworks, Zymergen, Culture Biosciences

🌱 Autonomous Finance Pilot deployments now, mainstream adoption 2027-2028

AI agents managing financial operations, from treasury to accounting to compliance

Why Now:

CFO workloads increasing, AI reaching accuracy thresholds for financial tasks

Market Potential:

$25B+ market replacing manual financial operations

Early signals from: Sequoia, Index, Lightspeed

Companies to watch: Ramp, Brex, Modern Treasury

❄️ Cooling Sectors

❄️ Consumer Social

Previous: Red hot during COVID/2021 boom → Now: Significantly cooled, selective interest only

User acquisition costs skyrocketed, monetization challenges, regulatory scrutiny, market saturation

What Changed: iOS privacy changes killed performance marketing arbitrage, increased focus on business fundamentals over growth metrics

VCs Cautious: Benchmark, Greylock, General Catalyst

❄️ Direct-to-Consumer Brands

Previous: Pandemic darling sector → Now: Cold, few new investments

Customer acquisition costs unsustainable, supply chain disruptions, return to physical retail

What Changed: Unit economics never worked at scale, brand differentiation proved difficult to maintain

VCs Cautious: Forerunner, Lightspeed, Bessemer

❄️ Web3 Gaming

Previous: Massive hype in 2021-2022 → Now: Tepid interest, infrastructure-focused only

Play-to-earn models failed, user retention issues, crypto market volatility impact

What Changed: Market realized gaming mechanics more important than tokenomics, focus shifted to traditional gaming with blockchain elements

VCs Cautious: a16z crypto, Paradigm, Haun Ventures

👨‍💻 Founder Insights

AI Startup Positioning

Focus on specific use cases with clear ROI rather than general-purpose AI tools

💡 Pick one vertical, measure business impact in dollars saved/generated, build procurement-ready case studies

— Sequoia Capital

Fundraising Strategy

Show path to profitability within 18-24 months, not just growth metrics

💡 Build detailed unit economics model, demonstrate improving contribution margins, have contingency plans for different funding scenarios

— Benchmark

Go-to-Market

Bottom-up adoption beating top-down sales in current environment

💡 Build for individual users first, let them bring it to their teams, optimize for viral coefficients over enterprise sales cycles

— Greylock

Technical Moats

Data moats stronger than algorithm moats in AI companies

💡 Focus on proprietary data collection, build network effects that generate better data over time

— a16z

International Expansion

European expansion critical for AI companies due to regulatory head start

💡 Build GDPR compliance from day one, consider European entity for regulated verticals, hire European go-to-market early

— Index Ventures

💰 Deal Activity

Deal volume down 35% YoY but average deal size up 20%. Quality over quantity trend continues with VCs focusing on proven business models and clear paths to profitability.

🚀 Mega Rounds

Anthropic $2.3B

Series C • Lead: General Catalyst • Others: Lightspeed, Bessemer, Index

Validates continued investor appetite for AI infrastructure at massive scale, despite OpenAI competition

AI Foundation Models
Databricks $1.6B

Series I • Lead: T. Rowe Price • Others: a16z, Kleiner, Bessemer

Shows crossover investors betting big on AI data infrastructure ahead of likely IPO

Data Infrastructure
Stripe $1.1B

Series J • Lead: Sequoia • Others: General Catalyst, Index

Fintech infrastructure proving more resilient than consumer fintech, enabling global expansion

Fintech Infrastructure

🚪 Notable Exits

UiPath $18.5B

Acquisition by Microsoft • Key investors: Accel, CapitalG, Dragoneer

Enterprise automation with clear ROI attracts premium valuations from strategic acquirers

Figma $45B

IPO • Key investors: Greylock, Index, Kleiner

Design tools with network effects can achieve massive scale, validating bottom-up SaaS model

🎯 Contrarian Takes

Benchmark

Their View

Most AI startups will fail because they're solving fake problems

VS
Consensus

AI is transformative technology that will create massive value across all sectors

Reasoning: Real business problems already have solutions. AI applications need to be 10x better, not just marginally better

Their Bet: Investing only in AI applications with measurable business impact, avoiding horizontal AI tools